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Designed for high-sensitivity analysis, the LCMS-8080
triple quadrupole LC/MS/MS provides outstanding
sensitivity and quantitation performance.
Technologies Supporting the Best in Class Sensitivity and Robustness
High-Temperature Ion Source
Coaxial Hot Gas
High-efficiency desolvation is achieved by coaxially blowing high-temperature gas around the nebulizer gas. High-sensitivity analyses can be performed with ESI for wide variety of compounds even in the challenging matrices. The loss of sensitivity is suppressed even at high HPLC flow rates. The maximum HPLC flow rate applicable to ESI is 3 mL/min.
HSID [Hot Source Induced Desolvation]
The multi-orthogonal inlet with heated device efficiently removes noise components during ion gas introduction. In addition, the exhaust system removes the interferences from ESI sprayer into the drainage which results in minimizing the instrument down time. As a result, the system can properly work out in long term without the need to clean or replace the ion source.
Plug-and-Play Ionization Probes
Plug-and-play instrument setup perfectly eliminates troublesome operations such as wiring and plumbing thanks to the cable-less ionization source design. The ionization probe position and needle protrusion is easily optimized without dismounting.
Performance by Design in an Unique Vertical Ion Path with the Smallest Footprint
The LCMS-8080 adapts a unique vertical ion path configuration incorporating multiple new technologies to enhance the sensitivity in challenging matrices. It requires just 50 x 50 cm footprints to save priceless laboratory space.
Achieving Best-in-Class Sensitivity
Shimadzu’s unique technologies, Coaxial Hot Gas and HSID ensure best-in-class sensitivity. With those technologies, LCMS-8080 meets with the requirements from scientists who needs the high sensitivity in the challenging matrices.
High-Temperature Ion Source Improves Sensitivity
The Coaxial Hot Gas technology accelerates ionization and desolvation. With reserpine for example, as shown in the figure at right, the signal intensity has been improved 8-fold. In addition, by utilizing Coaxial Hot Gas, a wide range of samples, from high polarity through medium to low polarity, can now be measured by ESI with high sensitivity.
At the HSID, the contact ratio between the ion plume and the heated path is increased. Subsequently, the efficiency of desolvation is improved and chemical noise is significantly reduced to maximize the S/N ratio. LCMS-8080 achieves the lowest detection limits at the femtogram to attogram level for a variety of compounds.
Furthermore, the 5-stage differential pumping system increase the introduction of ions and a laminar flow is formed by the Triple RF ion guide smoothly transfer the ions to quadruple analyzer.
Achieving Detection Limits in the Low Femtogram Range
The data at left is an MRM chromatogram for verapamil at 0.5 pg/mL.
Extremely good sensitivity has been obtained with a detection limit in the low femtogram region.
Column: Shim-pack XR-ODS III
2.0 mm I.D. × 50 mm L., 1.6 m
Mobile Phase: 5 mmol/L ammonium acetate – water / acetonitrile = 10 / 90
Flow rate: 0.5 mL/min
The data above is an MRM chromatogram for 3 pharmaceutical components at 5 pg/mL. In each case, the area repeatability (%RSD) is less than 6 %, a low noise level has been achieved, and the quantitation lower limit is several femtograms or less.
The data at left is an MRM chromatogram for testosterone, an important steroid. Steroids are comparatively low-polarity molecules and often measured by APCI. With the LCMS-8080, however, the extended compound coverage by ESI allows even moderately polar compounds such as steroids to be analyzed with good sensitivity. At 2 pg/mL, which is about to be the limit of quantitation, the area repeatability (%RSD) was 4.34 % in 6 replicates. The compound was detected with both high sensitivity and high precision.
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